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Acyl-HSL signaling & Quorum Quenching: screening and design on a new frontier in antimicrobial action

Dessalegne, Y. I. (2012) Acyl-HSL signaling & Quorum Quenching: screening and design on a new frontier in antimicrobial action. Bachelor's Thesis, Biology.

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Abstract

Quorum sensing, the ability of many bacterial colonies and communities to modify gene transcription in a density-dependent manner, is the mechanism by which biofilm formation occurs. Biofilms, communities of bacteria surrounding themselves with a robust extracellular matrix, cause infections to be difficult to treat with antibiotics. The pressure is on to find alternative antimicrobial molecules for these pathogens. This work is a description of recent screening and design efforts to inhibit the most well characterized quorum sensing signaling system, which uses N-acylated homoserinelactones (acyl-HSLs) as signals. Acyl-HSL signal degradation enzymes such as Acyl-HSL acylases and lactonases are widespread in prokaryotes, and naturally occurring small molecule inhibitors are produced by many plants. As more acyl-HSL system homologues are elucidated, more inhibitory molecules are discovered, and more 3D structures are resolved, rational design and screening of quorum sensing inhibitors is rapidly being refined.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:49
Last Modified: 15 Feb 2018 07:49
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/10353

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