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Cancer stem cells, the origin of breast tumors?

Weegh, T.J.A. op de (2012) Cancer stem cells, the origin of breast tumors? Bachelor's Thesis, Biology.

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Abstract

The origin of cancer remains an elusive feature that mainly is based on the incorporation of genetic changes during the replication cycle. There is increasing evidence that cancer initiation results from an increasing accumulation of genetic mutations in long living stem cells or their immediate progenitor cells. There are many different stem cells known and they can be divided into three main group's namely embryonic, germinal and somatic stem cells. In this paper we focus on the somatic stem cells that have the ability to self-renewal and to generate differentiated progeny for a lifetime in an organism in for example the bone marrow the breast and the brain tissue. Current evidence indicates that most cancers arise from a single cell that has undergone malignant transformation driven by frequent genetic mutations. These tumors contain rare cells with indefinite proliferative potential that drive the growth and the formation of tumors the so called cancer stem cells.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:50
Last Modified: 15 Feb 2018 07:50
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/10385

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