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Micro-RNAs as Regulators of Senescence and Aging

Roo, W. (2012) Micro-RNAs as Regulators of Senescence and Aging. Bachelor's Thesis, Biology.

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Abstract

Senescence is the change in the biology of an organism as it ages. It can be caused by different factors, and induced for different reasons. Aging is process, resulting from the accumulation of biological damage. Aging is closely connected to senescence, but has its own regulatory pathways. The p53 and p16 pathway are known to regulate senescence, while the IIS and TOR pathways are the best studied aging pathways. miRNAs have been found to regulate the mechanisms that control senescence and aging, and are also able to influence lifespan after up or down regulation. In this article I will discuss the major pathways that regulate senescence and aging, as well as sirtuins and shelterin. Sirtuins link metabolism to aging, and, acting through the TOR pathway, are another important group of regulators of lifespan. Shelterin is a protective cluster of proteins, safeguarding human telomeres and preventing premature senescence. These pathways and proteins are all involved in senescence and aging, and I will try to link them by a distinct group of cellular regulators; miRNAs.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:50
Last Modified: 15 Feb 2018 07:50
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/10439

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