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Essay : Fibroblast Positional Memory

Wouters, OY (2012) Essay : Fibroblast Positional Memory. Master's Thesis / Essay, Biology.

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Abstract

During embryogenesis in humans, 39 Hox genes in four different clusters are regulated in a temporal and spatial manner by epigenetics, giving rise to segmentation and specific cell differentiation. Studying gene expression, it was found that many different gene expression profiles exist, both in mesenchymal stem cells (MSC) and fibroblasts. These gene expression differences may lead to fibroblast plasticity, and ultimately gave rise to many different fibroblast subtypes. Furthermore, fibroblast Hox gene expression differences seems to be based on the location of the cell along the anatomic axes of the body, instead of being based on local interactions. Fibroblasts that are spatially close are not necessarily closely related, while distal fibroblasts gene expression profiles revealed striking similar ‘signatures’. This same ‘signature’ could also be found for MSC, showing similarities between bone marrow MSC (BM-MSC) and cord blood MSC (CB-MSC). Regulation of Hox genes seems to be complex, but might be partially regulated by several mechanisms via miR-21 in both MSC and fibroblasts. Other gene expression differences were found, showing a diverse heterogeneity in both fibroblasts and MSC populations.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 07:52
Last Modified: 15 Feb 2018 07:52
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/10802

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