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The potential of miRNAs in renal regeneration

Baars, A. L. (2013) The potential of miRNAs in renal regeneration. Bachelor's Thesis, Biology.

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Abstract

microRNAs (miRNAs) are small non-coding RNAs that regulate mRNAs at post-transcriptional level. This way, miRNAs can influence several target mRNAs and gene expression in an epigenetic fashion. Since the discovery of miRNAs, it has been found that miRNAs play a pivotal role in various organs, including the kidney. miRNAs contribute to kidney organogenesis and specific miRNAs are related to specific renal diseases. In addition, miRNAs have been examined for their potential to the regeneration of cardiac cells. It has been found that cardiac function in vivo can improve after the administration of specific miRNAs. Despite these findings, it is unclear whether those small molecules can contribute to renal regeneration as well. The aim of this thesis was to investigate whether miRNAs hold future prospects in the field of renal regenerative medicine. It was found that miRNAs hold the potential either to serve as therapeutical tools or as biomarkers, however, no studies are reported that examine regeneration in renal cells due to the application of miRNA. However, the function of miRNAs in renal disease is investigated at the moment. miRNA-192 and miRNA-21 can ameliorate fibrosis in diabetic nephropathy. Furthermore, miRNAs are necessary for tubular maturation. What is more, other strategies in renal regeneration such as organ repopulation or stem cell reprogramming evaluate renal regeneration. So far, these findings have only been demonstrated apart from each other. Therefore, it is suggested that miRNAs reported in organogenesis and disease be integrated with the above mentioned other renal regeneration strategies. Future studies that combine the aspects of cellular regeneration and fibrotic degeneration might be useful to address the question whether miRNAs can indeed help to regenerate renal function.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:53
Last Modified: 15 Feb 2018 07:53
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/11059

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