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Essay: Neutralizing antibodies, a protective shield against influenza

Stojanovska V, (2013) Essay: Neutralizing antibodies, a protective shield against influenza. Master's Thesis / Essay, Biology.

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Abstract

Introduction: Neutralizing antibodies have the ability to bind to antigens and to block their biological function. By targeting the surface antigens in viruses such as hemagglutinin (HA), influenza infection can be neutralized. Recent findings: With phage display libraries and single plasma cell isolation technique, neutralizing antibodies that cross-react with different subtypes of influenza were isolated. They target conserved regions in the hemagglutinin and block the binding of the virus to the receptors or the fusion of the virus with host cell membranes. When administrated in organisms, they elicit significant protection against influenza infection. Conclusion: Neutralizing antibodies that attack preserved antigenic epitopes in all subtypes of influenza can provide broad-spectrum of neutralization against influenza infection and can be used for passive immunization of the population or for developing of universal vaccines.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 07:53
Last Modified: 15 Feb 2018 07:53
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/11182

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