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The influence of Wall Teichoic Acids on cell viability and morphology in Bacillus subtilis

Wintgens, J.P. (2014) The influence of Wall Teichoic Acids on cell viability and morphology in Bacillus subtilis. Master's Thesis / Essay, Biology.

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Abstract

Wall teichoic acids (WTA’s) are negatively charged polymers that play an important role in the cell envelope. Among other functions they are influencing cell morphology and autolysin activity. The mechanism of the latter is only shown in Staphylococcus aureus and is poorly understood. We here show the impact on morphology by WTA’s in detail and started investigating the role of WTA’s in lysis in Bacillus subtilis. Lacking the first step in WTA biosynthesis the ΔtagO conditional knockout mutant was used to characterise growth under different wall teichoic acid concentrations. We found that growth is generally impaired and initially cannot be complemented to WT level.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:02
Last Modified: 15 Feb 2018 08:02
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/12419

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