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The potential role of HDACis in inflammation

Timmerman, T.M. (2015) The potential role of HDACis in inflammation. Master's Thesis / Essay, Biology.

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Abstract

Histones interact with DNA and fold it in typical structures which lead to the formation of chromatin. These histones undergo post-translational modifications caused by HATs and HDACs which can loosen or thighten the histone-DNA interaction. These enzymes are thereby involved in gene transcription by restricting or providing access for transcriptional proteins. HATs and HDACs are can also cause PTMs on non-histone targets. Increasing evidence suggests anti-inflammatory potential for HDAC inhibitors via the NF-κB pathway. In this report, based on recent publications, describes the role of class 1 HDACs in inflammation and the possibility of the use of HAD inhibitors for anti-inflammatory treatment.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:02
Last Modified: 15 Feb 2018 08:02
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/12515

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