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Deep brain stimulation effects on subthalamic nucleus oscillatory activity in Parkinson’s Disease

Buergers, S. (2015) Deep brain stimulation effects on subthalamic nucleus oscillatory activity in Parkinson’s Disease. Master's Thesis / Essay, Behavioural and Cognitive Neurosciences.

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Abstract

Objective: Deep brain stimulation (DBS) of basal ganglia nuclei such as the subthalamic nucleus (STN) is an effective treatment for symptoms of advanced Parkinson’s Disease (PD). Yet, its mechanism of action remains poorly understood. In newly implanted patients it is possible to record local field potentials from the DBS electrode. However, the stimulation artifact has a much greater magnitude than physiological activity making inference problematic. Current evidence suggests that oscillatory dynamics in subcortical structures might be altered in a manner similar to treatment with medication, which includes a suppression of neuronal synchronization in the β-band, i.e. at 13-30 Hz. Method: Here we investigate the oscillatory dynamics of local field potential recordings from the contralateral STN in response to unilateral DBS. Results: During active DBS artifacts are evident even in the contralateral STN. Post-stimulation effects are not apparent, but the high variability both between and within patients and prominent broadband artifacts throughout several recordings make quantitative conclusions problematic. Conclusions: Qualitatively β suppression seems to exist for some, but not all contralateral STN of PD patients. This study highlights the challenges, as well as the opportunities of post-operative local field potential recordings from the human subcortical structures.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Behavioural and Cognitive Neurosciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:03
Last Modified: 15 Feb 2018 08:03
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/12619

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