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Essay: Induced pluripotent stem cells as a source for dopaminergic neurons to treat and understand Parkinson’s disease

Maldonado, A. M. (2015) Essay: Induced pluripotent stem cells as a source for dopaminergic neurons to treat and understand Parkinson’s disease. Master's Thesis / Essay, Biology.

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Abstract

Parkinson’s disease (PD) is the most common neurodegenerative disease in elderly. It is characterized by the degeneration of the midbrain dopaminergic neurons in the substantia nigra leading to a decrease in dopamine production. For that reason, several treatments have been tested to improve dopamine production without offering a final solution in long-term for PD patients. Moreover, other approaches using cell implantation of fetal midbrain tissue into the brain of PD patients left unanswered questions considering the variability of conditions within each study. Since using fetal and embryonic cells involve issues as tissue availability and ethical bases, other alternatives sources as induced pluripotent stem cells (iPSC) have been proposed. Further, iPSC from mice and human sources have been tested in parkisonian animal models showing fair integration into the brain and improvement of motor behavior by using different protocols. In order to improve the efficiency of mDA neurons yield is important to underlie its differentiation process and mature phenotype to generate a proper protocol and to extend it to the clinic in a risk-safe way. In this review the main protocols used to generate iPS-mDA neurons to treat PD will be addressed.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:03
Last Modified: 15 Feb 2018 08:03
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/12643

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