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Essay:Deciphering intra-tumor heterogeneity from clonal evolution model, cancer stem cells model or CSCs evolution model

Lu, X (2015) Essay:Deciphering intra-tumor heterogeneity from clonal evolution model, cancer stem cells model or CSCs evolution model. Master's Thesis / Essay, Biology.

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Abstract

One major challenge in effective treatment of cancer is posed by intra-tumor heterogeneity. Understanding the mechanism for the derivation of intra-tumor heterogeneity can provide insight for precise determination of targeted therapeutic treatment and overcome drug resistance. Currently, there are two models that are proposed to explain the origin of phenotypic intra-tumor heterogeneity, i) the clonal evolution model that focuses on heritable origin of heterogeneity such as by genetic mutations and ii) the cancer stem cells (CSCs) model that focuses on non-heritable origin of heterogeneity such as by epigenetic changes, protein stability and micro-environment fluctuation. In this review, I will describe the two models and discuss the underlying concepts, supporting evidences, the limitation of each model and the methods available for the study of each model. Although these two models are often considered as mutually exclusive, recently it has been proposed that these two models can be harmonized into a CSCs evolution model. The methods that can be applied to explore the extent to which intra-tumor heterogeneity can be explained by CSCs evolution model are not yet established. To fill this gap, I propose several new ideas to adapt the existing computational method, such as metabolic network modeling and comprehensive comparative analysis, in order to better explain the intra-tumor heterogeneity and identify relevant therapeutic targets.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:03
Last Modified: 15 Feb 2018 08:03
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/12653

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