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Inhibition of the bacterial cell-division protein FtsZ: advances in the development of new antibiotics

Mous, S.T.M. (2015) Inhibition of the bacterial cell-division protein FtsZ: advances in the development of new antibiotics. Bachelor's Thesis, Biology.

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Abstract

Antimicrobial resistance is emerging globally and there is a rising need for new antibiotics. A new and promising class of antibiotics that is currently being developed targets bacterial cell division. One of the essential cell division proteins that can be targeted is FtsZ. FtsZ is widely conserved among bacteria. This important protein forms the Z-ring during cell division. The Z-ring acts as a scaffold for the formation of the divisome, a complex of proteins that regulates cytokinesis. This thesis describes the advances in the discovery and development of FtsZ inhibitors. Different in vivo and in vitro assays that are commonly used for the discovery of new FtsZ inhibitors are discussed, together with the limitations of these techniques. Also, an overview concerning the research that has been done on FtsZ inhibitors in the past few years is provided. This overview shows that many potential FtsZ inhibitors have been identified in the last few years, but many false positives were also reported. The most promising compounds to date were found to be PC190723, zantrin Z3 and C8-GTP analogues. These compounds can be used for the development of new antibiotics, to combat the increasing amount of multidrug resistant pathogens.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:03
Last Modified: 15 Feb 2018 08:03
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/12662

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