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Nonribosomal Peptide Synthetases

Dijkstra, B.A. (2015) Nonribosomal Peptide Synthetases. Bachelor's Thesis, Biology.

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Abstract

Nonribosomal peptide synthetases (NRPS) are multimodular mega-proteins. They are able to use nonproteinogenic amino acids, and are used by bacteria and fungi to produce secondary metabolites. This includes many of the known antibacterial and anti-fungal compounds known today. In this thesis the function and mechanisms of NRPSs are discussed. We look at the function of the many different domains used by these proteins, and give an overview of the different catalyzed reactions. Also the organization of the modules and how they interact on a structural level is shown. Finally a number of different methods for NRPS manipulation and obtaining novel peptides are discussed.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:04
Last Modified: 15 Feb 2018 08:04
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/12730

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