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Research Report 2: Investigating the epigenetic state of young and aged mouse hematopoietic stem cells

Marring, I. (2015) Research Report 2: Investigating the epigenetic state of young and aged mouse hematopoietic stem cells. Master's Thesis / Essay, Biology.

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Abstract

Hematopoietic stem cells produce all types of blood cells and are known for their self-renewal capacity, but are nevertheless prone to the detrimental effects of aging, such as a deteriorated immune functioning and a higher incidence of myeloid malignancies. Histone posttranslational modifications (PTMs) play a role in gene expression and silencing. One form of PTMs, epigenetic modifications, is being studied for their possible contribution to the aging of the hematopoietic system. A protocol for intracellular FACS staining was optimized to quantify the amount of H3K4me3, H3K27me3, H3K27ac and H3K9ac marks in LT-HSCs isolated from young and old mice.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:09
Last Modified: 15 Feb 2018 08:09
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/13382

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