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Essay: Therapeutic Targeting of Kinases and Phosphatases to Inhibit Microvascular Leakage in Sepsis

Luxen, M. (2015) Essay: Therapeutic Targeting of Kinases and Phosphatases to Inhibit Microvascular Leakage in Sepsis. Master's Thesis / Essay, Biology.

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Abstract

Abstract. Sepsis and septic shock are poorly understood and have mortality rates as high as 50% due to microvascular leakage, tissue hypoxia, and organ damage and subsequent organ failure in patients. Microvascular leakage is caused by activation of endothelial cells and dysfunction of the endothelial barrier. Currently, no drug is available to ameliorate microvascular leakage. Therefore, this review explores sphingosine-1-phosphate (S1P), Rho-associated protein kinase (ROCK), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and tunica intima endothelial kinase 2 (Tie2) as possible pathways to restore the endothelial barrier function in sepsis. Specifically, each of these pathways encompasses kinases and phosphatases which are highlighted as possible therapeutic targets in sepsis. Finally, recommendations are made concerning the use of animal models in the development of sepsis drugs.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:09
Last Modified: 15 Feb 2018 08:09
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/13488

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