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Essay: TNF in neuroinflammation; what can be learned from TNF research in non-neuronal autoimmune diseases

Miedema, T (2016) Essay: TNF in neuroinflammation; what can be learned from TNF research in non-neuronal autoimmune diseases. Bachelor's Thesis, Biology.

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Abstract

Abstract Tumor necrosis factor (TNF) plays an important role in inflammation. It is thought to be a key mediator in neurodegenerative disorders such as Alzheimer’s disease (AD), Multiple sclerosis (MS), and ischemic stroke. TNF’s role as immune modulator makes it a potential target for therapy in neurodegenerative disorders. Despite that there have been many studies regarding the effect of TNF and its signaling pathways via its two receptors, namely TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), there is still much unknown. TNF research is not only limited to neuroscience on the contrary, TNF is a potent modulator in most inflammatory responses including autoimmune diseases. There have been loads of studies and trials regarding the role of TNF in autoimmune diseases such as: granulomatosis with polyangiitis (GPA), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), diabetes, and Sjögren’s syndrome (SS). Anti-TNF therapy is widely used as treatment of RA and this gives insights on the effect of treatment on inflammation. The following essay focuses on the role of TNF in neurodegenerative diseases and how TNF and anti-TNF treatment in non-neurodegenerative autoimmune disorders may contribute to a better understanding of its involvement in neuroinflammation.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:11
Last Modified: 15 Feb 2018 08:11
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/13687

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