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The role of A-kinase anchoring proteins (AKAPs) in the pathophysiology of chronic obstructive pulmonary disease (COPD)

Visser, K.J. (2016) The role of A-kinase anchoring proteins (AKAPs) in the pathophysiology of chronic obstructive pulmonary disease (COPD). Bachelor's Thesis, Biology.

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Abstract

Chronic obstructive pulmonary disease (COPD) is an increasing global health problem and leading cause of disability and death. The disease is characterised by chronic inflammation due to increased levels of cytokines and chemokines as well as alveolar neutrophils, macrophages and T-lymphocytes. and will result in loss of lung elasticity and mucus hypersecretion. Also, due to exposure to noxious substances, like cigarette smoke extract, levels of reactive oxygen species (ROS) increase inducing damage to lipids, proteins and DNA. These responses originate from signal transduction mechanisms which are controlled by compartmentalization of cAMP-dependent protein kinase (PKA) which are bound to A-kinase anchoring proteins (AKAPs). The highly conserved members of the AKAP ensures spatial-temporal control of important signal transduction mechanisms. Dyregulation of AKAPs is related to a number of disorders like neurodegenerative disease, cardiovascular disease and COPD. This assay will focus on the role of AKAPs in the respiratory tract and the pathophysiology of COPD.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:11
Last Modified: 15 Feb 2018 08:11
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/13755

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