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The role of endothelial cilia in shear stress sensing in (patho)physiology.

Westerling, M.H. (2016) The role of endothelial cilia in shear stress sensing in (patho)physiology. Bachelor's Thesis, Biology.

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Abstract

Endothelial cells are constantly exposed to shear stress. When the shear stress becomes higher, endothelial cells sense the change and release vasodilation agents. To sense shear stress, endothelial cells contain mechanosensors, such as primary cilia. When the cilium senses shear stress by bending, a calcium influx is created. This calcium influx activates a cascade of reactions, which eventually leads to an activation of nitric oxide. Primary cilia are relatively new as a mechanosensor and the mechanism in which the cilium senses shear stress is not fully understood. In some diseases, such as Atherosclerosis, the expression of primary cilia is changed. This review will inquire the role of cilia in mechanosensing in (patho)physiology.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:13
Last Modified: 15 Feb 2018 08:13
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/14138

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