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Cancer Metabolism: Involvement in Oncogenesis and Cancer Development Provides New Therapeutic Targets

Leest, P. van der (2016) Cancer Metabolism: Involvement in Oncogenesis and Cancer Development Provides New Therapeutic Targets. Bachelor's Thesis, Biology.

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Abstract

Metabolic regulation is an important new target in the battle against cancer. Through history, cancer metabolism has been underestimated. Metabolic research of cancer started promising with the discovery of aerobic glycolysis, known as the Warburg effect, but cancer studies mainly focused on other aspects. Only in recent years, research in cancer metabolism is rejuvenated and is considered hallmark in oncogenesis and cancer development. Cancer cells experience metabolic alterations which change energy production, biosynthesis and replicative behavior among others. Together, these cellular changes provide an altered physiological state which distinguishes them from heathy cells. Many oncogenes and tumor-suppressor genes are involved in the shifted metabolic regulation of cancer. Iconic cancer genes like Myc and p53 have great influence on regulatory pathways responsible for the metabolic shift. Lots of genes involved show completely different functions in cancer cells compared to normal cells; thereby provide new targets for drug development. The metabolic alterations include cellular changes necessary for metastasis. Regarding metastasis, metabolic regulators and environmental circumstances enable cells to leave their own original location and migrate to another tissue. Metastasizing cancer cells enhances the pathology and, eventually, contribute a great deal to cancer-induced mortality. In order to prevent cancer development, metastasis and the underlying pathology, promising research to develop metabolic interventions has been initiated. Metabolic interventions have the potential to become the new solution in the battle against cancer.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:14
Last Modified: 15 Feb 2018 08:14
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/14236

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