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The role of IL-13 in the pathogenesis of classical Hodgkin lymphoma

Baars, I (2016) The role of IL-13 in the pathogenesis of classical Hodgkin lymphoma. Research Project 1 (minor thesis), Biomedical Sciences.

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Abstract

The cytokine IL-13 has been suggested to stimulate proliferation of Hodgkin Reed–Sternberg cells, the malignant cells in classical Hodgkin lymphoma (cHL), through phosphorylation of STAT6. A recent GWAS study found an association between cHL and the rs20541 IL-13 variant, which has been considered to have increased activity. However, the effects of wild-type and variant IL-13 on the pathogenesis of cHL are still unclear. Therefore, the effects of wild-type and variant IL-13 on cell growth and phosphorylation of STAT6 in cHL were investigated in the current study. We show here that certain cHL cell lines express IL-13 and that phosphorylation of STAT6 is dependent on IL-13. Moreover, antibody-mediated inhibition of IL-13 decreases cell growth in L428, a nodular sclerosis (NS) cell line, but not in L1236, a mixed cellularity cell line. No differences between wild-type and variant IL-13 on cell growth were observed. These results suggest that IL-13 is an important growth factor in certain cHL subtypes, such as NS and that the rs20541 IL-13 variant does not have increased activity compared to wild-type IL-13.

Item Type: Thesis (Research Project 1 (minor thesis))
Degree programme: Biomedical Sciences
Thesis type: Research Project 1 (minor thesis)
Language: English
Date Deposited: 15 Feb 2018 08:23
Last Modified: 15 Feb 2018 08:24
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/14341

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