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X-Ray photoionization of DNA-nanoparticle complexes

Castellano E., (2016) X-Ray photoionization of DNA-nanoparticle complexes. Master's Thesis / Essay, Physics.

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Abstract

The radiotherapy treatment based on high-energy photons is nowadays commonly used to treat cancer. There are numerous theoretical studies that have been carried out investigations on the viability of metal nanoparticles as contrast agents in radiotherapy treatments. These studies have shown that the relative dose to tissue volumes can be significantly increased by the addition of these nanoparticles due to their larger X-ray absorption cross section as compared to biological tissue. In this project we want to study the processes underlying the interaction between photons and a complex consisting of a metal nanoparticle and DNA. In particular it will be investigated whether Auger electrons are playing a crucial role in this interaction, as many studies suggest. In order to bring the major conclusions within thin this context, we have carried out experiments related to the fragmentation of DNA strands induced by soft X-ray photoionization and photoexcitation. Furthermore, novel approaches for the production of complexes of small functionalized AgN:DNA were investigated.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Physics
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:25
Last Modified: 15 Feb 2018 08:25
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/14532

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