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Essay: Phospholipid Bilayers; Mechanisms behind vesicle fusion as determined from computer simulations and experiments.

Mulder, G. A. (2016) Essay: Phospholipid Bilayers; Mechanisms behind vesicle fusion as determined from computer simulations and experiments. Bachelor's Thesis, Biology.

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Abstract

In this article, the process of phospholipid bilayer fusion is discussed. As molecular dynamics simulations are a widely used method to obtain information on the behaviour of molecules, a short explanation is given of these techniques. Following this, the stalk-pore fusion theory is explained by discussing its various intermediary states. Attention will go towards explaining the dynamic processes that the system undergoes and how scientific experiments support these claims. After this, the stalk-pore fusion theory, which applies to pure phospholipid bilayer fusion, is tied to assisted fusion as it occurs in biological systems. First, the effects of ions on fusion are discussed. Then, the role of the SNARE protein in speeding up of fusion is explained. Next, DNA as a synthetic substitute for these SNARE proteins is evaluated. Lastly, the molecular machinery of viruses and the way they induce membrane fusion is considered. This article closes with a summary of the presented information and ends with a few remarks on the future of this field of study.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:25
Last Modified: 15 Feb 2018 08:25
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/14533

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