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Leukaemia: Genetic or Epigenetic Disorder? A Clarion Call for the Revision of the Two-Hit Hypothesis in Myeloid Leukaemogenesis

Groothof, D. (2016) Leukaemia: Genetic or Epigenetic Disorder? A Clarion Call for the Revision of the Two-Hit Hypothesis in Myeloid Leukaemogenesis. Bachelor's Thesis, Biology.

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Abstract

Over the past decades cancer research profoundly improved our understanding of tumour biology, which allowed for the development of efficient therapeutic strategies in several malignancies, thereby improving prognoses. However, particularly in the elderly, long-term disease free survival in leukaemia still remains a problematic hurdle. Leukaemic cells prove to be very resistant to conventional chemotherapy that is, and the majority of patients showing complete remission after revised intensive chemotherapeutic regimens eventually relapse despite receiving post-remission therapy. Yet, novel insights strongly convey the impression that a solution might be near at hand. By focussing upon acute myeloid leukaemia, the present thesis demonstrates that leukaemia truly is more than a mere genetic disorder, and how this finding can potentially be put to use in the development of novel therapeutic strategies.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:25
Last Modified: 15 Feb 2018 08:25
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/14544

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