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Using DNA damage repair system from model organisms to study human Cancers and DNA damage repairs: A valid approach?

Jalnapurkar B.V., (2016) Using DNA damage repair system from model organisms to study human Cancers and DNA damage repairs: A valid approach? Master's Thesis / Essay, Molecular Biology and Biotechnology.

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Abstract

DNA damages left unrepaired which accumulate in course of time are one of the most important causative agents of cancer. With aging inherent DNA damage repair systems suffer a loss of efficiency to repair DNA damages. It is evident that DNA repair genes are gatekeepers of cancer and hence defective or inadequate DNA damage repair systems do play the key role in the development of cancer. Because of cancer in affects multiple organs and systems in humans, it becomes a most challenging job to model these processes in the lab. So far the cancer research has been dominated by non-vertebrate short-lived model organisms such as yeast (S. cerevisiae), worm (C. elegans) and fly (D. melanogaster) that has enabled the identification of remarkably conserved aging-related pathways. In spite of this, some important aspects of human cancer and disease phenotypes cannot be confidently recapitulated in invertebrate models as they are devoid of specific organs and systems that are crucial components of human cancers. Vertebrates model systems; mouse (M. musculus) and zebrafish (D. rerio) have also been utilized in cancer research. Still, experimental studies have been affected by the comparatively long life span of mice and zebrafish and their high maintenance costs particularly mice. Mouse models with accelerated onset of age-related diseases can address the cancer medical conditions in parts but they still need detailed studies to discover the role of the DNA damages which accumulate during aging and failed DNA damage repair systems in the cancer progression. All these issues related to model organisms available at present led to the need of the new vertebrate model of DNA damage repair systems that can be ultimately translated into the humans for cancer treatments and prevention.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Molecular Biology and Biotechnology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:25
Last Modified: 15 Feb 2018 08:25
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/14622

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