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Hurdles in the development of mRNA-based therapeutics; current position and future approach

Stempels, F.C. (2017) Hurdles in the development of mRNA-based therapeutics; current position and future approach. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

Gene therapy is the delivery of nucleic acids into a patient's cells to treat or prevent a disease. mRNA-based therapeutics have many advantages over both pDNA- and siRNA-based therapeutics. mRNA therapeutics can be applied in the treatment of genetic disorders, regenerative medicine and in the treatment of infective and neoplastic disorders. Although mRNA was previously considered too instable to form a therapeutic, many techniques show effective mRNA transfection. This essay discusses the status quo in the field of mRNA modifications and a variety of mRNA delivery methods among which complex-forming delivery materials, techniques used for targeting of the mRNA, electroporation and gene gun delivery. Although the general principles behind effective mRNA delivery have yet remained largely unclear, several techniques generated effective mRNA transfection. In combination with the broad range of applications, this pleads for more research in the field of mRNA-based therapeutics.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:27
Last Modified: 15 Feb 2018 08:27
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/14983

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