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Effects of single and repeated electroconvulsive shocks on brain C-Fos activity and LPS-induced behavioral changes.

van Drunen, J.J.E. (2017) Effects of single and repeated electroconvulsive shocks on brain C-Fos activity and LPS-induced behavioral changes. Research Project 2 (major thesis), Biomedical Sciences.

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Abstract

While electroconvulsive shocks (ECS) have long been used as an effective treatment for major depressive disorder (MDD), its underlying mechanisms remain largely unknown. Recent studies suggest that changes in the brain immune system which result from repeated ECS may contribute to the effectiveness of the treatment. The current project seeks to clarify two aspects of this potential underlying mechanism. Firstly, it tests whether repeated ECS treatments have a different effect on brain C-Fos activity in mice, compared to single treatments. Secondly, it tests whether repeated ECS can protect mice against LPS induced depression-like behavior. Both single and repeated ECS significantly increased C-Fos activity short term, but not long term. In the second experiment, LPS failed to induce significant depression-like behavior. Therefore, we cannot draw definitive conclusions regarding the possible protective effects of repeated ECS on LPS-induced behavioral changes.

Item Type: Thesis (Research Project 2 (major thesis))
Degree programme: Biomedical Sciences
Thesis type: Research Project 2 (major thesis)
Language: English
Date Deposited: 15 Feb 2018 08:27
Last Modified: 15 Feb 2018 08:27
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/15070

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