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Mutations and aneuploidy in lung cancer

Deiman, F.E. (2017) Mutations and aneuploidy in lung cancer. Bachelor's Thesis, Biology.

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Abstract

The deadliest type of cancer in this world is lung cancer. This is a cancer type characterized by growth of a malignant tumor on pulmonary tissue. This thesis focuses on finding the significantly mutated genes and karyotypes found in lung squamous cell carcinoma, lung adenocarcinoma and small cell lung cancer and to furthermore see whether there is correlation between these two genomic aberrations. In order to establish the significantly mutated genes found in lung cancer, the cancer genome atlas and its derived articles were used. Various significantly mutated genes were found that could be involved in lung cancer. There were also subtype specific genes found that could contribute to this specific type of lung cancer. The karyotypes found within the various types of lung cancer were determined using the Mitelman database of chromosome aberrations and gene fusions in cancer. With the help of this database the rates of missing and extra copies of chromosomes per subtype were established. By comparing the chromosomal locations of the significantly mutated genes and the karyotypes we were able to establish that there definitely is some degree of correlation between these two genomic aberrations. Studying these genomic aberrations can help us find therapeutic targets, which can be used to create a therapy for this deadly disease.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:27
Last Modified: 15 Feb 2018 08:27
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/15090

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