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Recent Advances in PROTAC Technology towards BET Protein Targets for Cancer Treatment

Haan, M.P. de (2017) Recent Advances in PROTAC Technology towards BET Protein Targets for Cancer Treatment. Master's Thesis / Essay, Chemistry.

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Abstract

This report describes the recent advancements in PROTAC technology specifically targeting BET proteins, with a focus on the BRD4 protein. It gives an overview of the progress in the employment of this new technology and its anti cancer capabilities. PROTAC, meaning Proteolysis Targeting Chimeraes are molecules made up of 3 parts: A target binding moiety, an E3 ligase recruiting moiety and a linker to connect them. It uses the cell's ubiquitinilation machinery to degrade a target protein. The limitations and advantages of this new technology is discussed.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Chemistry
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:28
Last Modified: 15 Feb 2018 08:28
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/15169

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