Thesis: Mechanisms of antibiotic resistance in Acinetobacter baumannii

Bartelds, M. W. (2017) Thesis: Mechanisms of antibiotic resistance in Acinetobacter baumannii. Bachelor's Thesis, Biology.

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Abstract

A. baumannii is an organism of great concern to modern health care. The main reason for it is its availability to become resistant against all known antibiotics. In this review the mechanisms behind drug resistance are described. The molecular mechanisms can be divided into four groups: reduced permeability, antibiotic modification, alteration of the targets or protecting the target by expressing a secondary protein. A. baumannii possesses mechanisms belonging to all four groups, but the most important is the first. A. baumannii is intrinsically very impermeable for many antibiotics and this leads to significant levels of multidrug resistance. To drugs that are capable of surpassing this first line of defence multiple mostly drug specific defence mechanisms are reported in clinical isolates. Although the genetic diversity among A. baumannii isolates is very high the molecular mechanisms behind the impermeablity are conserved. Therefore future drugs should be designed in such a way that they can permeate into the cell and evade the efflux systems.

Item Type:	Thesis (Bachelor's Thesis)
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	15 Feb 2018 08:29
Last Modified:	15 Feb 2018 08:29
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/15323

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