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Using 3D bio-printing for the development of human organs and tissues

Bakker, K.J. (2017) Using 3D bio-printing for the development of human organs and tissues. Bachelor's Thesis, Biology.

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Abstract

Since 1950 organ transplantation has been very helpful and live saving for millions of people worldwide. There is a growing shortage of donor organs and new alternatives for transplantation have been investigated already. 3D bio-printing of cell-laden scaffolds or even entire tissues and organs has been emerged over the last decade and there are already several applications for 3D bio-printing. To find out if 3D bio-printing of tissues or organs is a reasonable alternative to transplantation, the main question in this review is: “Is 3D bio-printing of tissues or organs a possible solution for patients who need a donor organ?” The 3D bio-printing procedure contains multiple steps to design a desired construct. Imaging can help to design the proper shape and structure of the produced artificial bio-tissue and computer-aided design (CAD) and mathematical modeling can be used to assemble and digitalize the information about structure and shape for reconstruction. Subsequently, the information can be converted into two dimensional slices and referred to the 3D bio-printer. Different cellular bio-printing methods use other bio-ink deposition mechanisms and in printing modality. Common cellular bio-printing methods are droplet based, extrusion based or stereolithography based techniques, which distinguish themselves in available bio-materials, resolution, printing speed and cell viability. Bio-inks contain biomaterials, biochemical agents and cells. Bio-inks can be deposited in different specific patterns and can be printed with or without scaffolds. Besides a specific deposition pattern to form a stable construct, the composition of bio-inks also is important for the strength and function of the 3D construct.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:30
Last Modified: 15 Feb 2018 08:30
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/15493

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