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Efficient production of solid dispersions by spray drying solutions of high solid contents using a 3-fluid nozzle

Broekhuis, J. (2017) Efficient production of solid dispersions by spray drying solutions of high solid contents using a 3-fluid nozzle. Master's Thesis / Essay, Industrial Engineering and Management.

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Abstract

To check the feasibility of producing solid dispersions with 3-fluid nozzle spray drying to enhance bioavailability, 60 experiments were done based on a Design of Experiment. Solid dispersions of mannitol and diazepam with a drug load of 20% were produced. The variables of the experiments were the water/organic solvent ratio, liquid feed flow, total solid content, atomizing airflow and type of organic solvent (ethanol or ethyl acetate). The responses that were measured were dissolution time t80¬¬, yield, particle size, actual drug load and crystallinity of diazepam. Increasing water/organic solvent ratio was found to be the main factor for improving the dissolution rate. The total solid content did not affect any of the responses, which means that working with high concentrations is possible. The choice of organic solvent did not affect the responses as well, which means that miscible and immiscible organic solvent can be used in the production of solid dispersions.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Industrial Engineering and Management
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:33
Last Modified: 15 Feb 2018 08:33
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/16125

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