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ATG4 as a drug target for autophagy modulation in disease

Lara, Stefano (2017) ATG4 as a drug target for autophagy modulation in disease. Master's Thesis / Essay, Medical Pharmaceutical Sciences.

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Abstract

Autophagy is a survival mechanism that is present in all eukaryotic cells, and it is positively regulated under stress conditions, e.g. during nutrient or oxygen deprivation. It has been linked to a number of diseases, including cancer, neurological disorders and infectious diseases. As a result, its regulation provides an interesting approach to target such diseases. The accurate modulation of autophagy is a challenging task, as many different mediators play a role in this pathway. Among these mediators, the ATG4 cysteine proteases show a lot of potential, as they are essential for autophagy, playing key roles in both the conjugation and deconjugation processes. Nonetheless, targeting ATG4 in order to modulate autophagy has shown to be of high complexity because it is tightly regulated by an intricate network of components, and further research is needed to help elucidate how the whole machinery works coordinately. Consequently, I mainly focused in this essay on the state of the art research regarding ATG4 functions, regulation and drug discovery.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Medical Pharmaceutical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:33
Last Modified: 15 Feb 2018 08:33
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/16181

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