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Fate specification of embryonic neocortical neuronal progenitor cells and the generation of projection neuron diversity.

Bokern, K.A. (2017) Fate specification of embryonic neocortical neuronal progenitor cells and the generation of projection neuron diversity. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

The neocortex in the mammalian brain exhibits an incredible diversity of projection neurons, despite these cells being embryonically derived from a small number of neuronal progenitor cells in one germinal zone. Projection neuron diversity is observed in morphology, function, electrophysiological properties, axonal projections, molecular identity and genome-wide expression profiles. Complex molecular and cellular processes regulate cell fate specification of neocortical neuronal progenitor cells during mammalian embryonic development. Distinct types of neuronal progenitor cells are present during different phases of development, locate to different regions of the neocortical germinal zone and in specific cases generate progeny with different characteristics. In recent years the dynamics of progenitor competence have become a controversial topic and two scientific models can describe it: progressive restriction of fate potential, which was first explored in Drosophila, and fate-restricted lineages. Further understanding of neocortical neuronal fate specification is potentially useful for research on brain development and disease, and the design of brain repair therapies.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:34
Last Modified: 15 Feb 2018 08:34
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/16319

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