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The effects of pre-eclampsia and uterine growth restriction on changes of redox status during pregnancy.

Dijkstra, T. (2018) The effects of pre-eclampsia and uterine growth restriction on changes of redox status during pregnancy. Master's Thesis / Essay, Science Education and Communication.

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The placenta regulates fetal growth and development during pregnancy. In healthy women, the development of the placenta is established by the remodelling of spiral arteries by extra villous trophoblasts, resulting in an adequate supply of oxygen and nutrients for the fetus. In case of pregnancy complications, remodelling of the spiral arteries has been suboptimal causing an suboptimal placental function. This can result in changes in the redox status, characterized by an increase in oxidative stress. In this study, free thiol concentrations in serum and/or urine of women suffering preeclampsia (PE) and/or fetal growth restriction (FGR) are measured to determine the presence of oxidative stress. Free thiols, which can be measured in urine and serum, are known as a biomarker for oxidative stress. They function as an antioxidant in the human body, whereby decreased concentrations illustrate a systemic environment with high amounts of oxidative stress. The results show that women suffering from PE have decreased concentrations of free thiols in urine and blood, when compared to healthy pregnant women. In the future, thiol concentrations in urine and serum may be measured during the first trimester of a pregnancy to predict the possibility of development of pregnancy complications. Antioxidant therapies may then be used during pregnancy to prevent the development of PE/FGR.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor nameSupervisor E mail
Degree programme: Science Education and Communication
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:35
Last Modified: 25 Apr 2019 10:55

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