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The role of organoids in Cystic Fibrosis research

Woertink, Jacolien (2018) The role of organoids in Cystic Fibrosis research. Bachelor's Thesis, Life Science and Technology.

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Abstract

Cystic Fibrosis (CF) is a hereditary disease, caused by a mutation in the CFTR channel resulting in CFTR dysfunction. CFTR modulators are medicine that will attempt to restore the CFTR function. To assist CF patients better, it is important to know the individual response on CFTR modulators, striving to personalized medicine. Therefore, researchers are currently performing research on new methods using an organoid model. Organoids are 3D structures, like ‘mini-organs’ and useful because of their characteristics, such as self-organization and multicellularity. Intestinal organoids were highlighted, because the intestine is also affected in CF. The aim of this thesis is to get a clear image of the role of organoids in study and treatment of Cystic Fibrosis. Two methods will be highlighted: Forskolin Induced Swelling (FIS) assay and the CRISP/Cas9 technology. Both methods are using an organoid model and are hopeful approaches to realizing personalized medicine and develop the knowledge about CF.

Item Type: Thesis (Bachelor's Thesis)
Supervisor:
Supervisor nameSupervisor E mail
Coppes, R.P.r.p.coppes@umcg.nl
Degree programme: Life Science and Technology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 05 Jul 2018
Last Modified: 06 Jul 2018 07:28
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/17601

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