Russel, Stefan Alfred Hendrik (2018) Precision-cut kidney slices as a model for acute kidney injury. Research Project, Pharmacy.
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Abstract
Acute kidney injury (AKI) is worldwide a major health concern and the incidence has increased over time. There is, as of now, no medical intervention that significantly impacts AKI. A factor that can cause AKI is ischemia/reperfusion injury (IRI), which is restriction of blood to the kidney followed by restored blood flow. Mitochondrial dysfunction plays a critical role in the progression of renal IRI. Here, we looked at murine precision-cut kidney slices (PCKS) as a model for renal IRI. Furthermore, a compound that theoretically improves mitochondrial functionality, SUL-138, was added during incubation to possibly combat kidney IRI
| Item Type: | Thesis (Research Project) |
|---|---|
| Supervisor name: | Graaf, I.A.M. de |
| Degree programme: | Pharmacy |
| Thesis type: | Research Project |
| Date Deposited: | 03 Sep 2018 |
| Last Modified: | 12 Jul 2019 12:11 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/18500 |
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