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LRRK2: where do we stand and where to go?

Dam, Wiebe (2018) LRRK2: where do we stand and where to go? Bachelor's Thesis, Biology.

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Abstract

Parkinson’s disease is the second most prevalent neurodegenerative disease and the most common genetic cause of late-onset Parkinson’s is a mutated gene called LRRK2. Named after a domain it possesses, LRRK2 consists of multiple protein interaction domains like kinase, WD40, Roc and Cor domains and LRR repeats. It is also involved in a legion of processes and its interactome is huge. Where its suspected role in Parkinson’s seems to be well substantiated, a lot is still unknown about LRRK2. Combining research, this thesis discusses several aspects of LRRK2 with the aims to clarify almost 15 years of research and to add a possible outlook for the future. LRRK2’s different domains, mutations and mechanisms of activation are discussed and combined with possible therapeutic strategies that can be enforced when LRRK2 in Parkinson’s disease is targeted. Where research has mainly had its focus on the inhibition of LRRK2 kinase, other therapeutic strategies like the disruption of dimerization, interference on the protein-protein interaction platform and disruption of localisation seem to remain underexposed. While research has put out some negative outcome, the development of current drugs and the possibilities that have yet to be researched look promising.

Item Type: Thesis (Bachelor's Thesis)
Supervisor:
Supervisor nameSupervisor E mail
Kortholt, A.A.Kortholt@rug.nl
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 02 Nov 2018
Last Modified: 08 Nov 2018 08:52
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/18779

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