Ivanov, Ilya (2018) Therapeutic significance of exosomes as a drug delivery system. Application: Parkinson's disease. Master's Thesis / Essay, Molecular Biology and Biotechnology (2016-2019).
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Abstract
Exosomes are nanovesicles secreted by all cell types and can be found in all body fluids. They carry a cell-specific composition of membrane phospholipids and biomolecules. Exosome biogenesis and composition is mediated by a number of precise mechanisms. In this review, exosomes will be addressed as drug delivery vesicles for treatment of Parkinson’s disease. PD targeting requires the crossing of the blood-brain barrier and exosomes are able to do so. Various therapeutic cargo molecules can be loaded into exosomes ex vivo, such as curcumin, dopamine or mRNA. Exosomes appear to be a prominent drug delivery system due to their biocompatibility, versatility, and the ability to preserve cargo catalytic activity and to cross the BBB. This last one is essential for all CNS diseases, including PD. Different therapeutic strategies for PD treatment and therapeutic cargo incorporation in exosomes for drug delivery to the brain are the main topics addressed in this review.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Linskens, M.H.K. |
| Degree programme: | Molecular Biology and Biotechnology (2016-2019) |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 22 Nov 2018 |
| Last Modified: | 03 Dec 2018 13:23 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/18842 |
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