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Cancer cell proliferation being manipulated by SSRIs via multiple pathways, resulting in cancer cell apoptosis

Ridder, de, Lars (2019) Cancer cell proliferation being manipulated by SSRIs via multiple pathways, resulting in cancer cell apoptosis. Bachelor's Thesis, Life Science and Technology.

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Abstract

There are indications that SSRIs have a dual-purpose in cancer treatment. Firstly, they target depressions and secondly they are involved in multiple intracellular pathways involved in (cancer) cell proliferation and apoptosis. It has been shown SSRIs activate multiple pathways involved in the induction of cancer cell apoptosis, including the Raf-Ras-MEK-ERK pathway, the JNK pathway and SSRIs induce excessive Ca2+ influx. Activation of these pathways leads to increased amounts of apoptotic factors like caspase-3, caspase-7 and caspase-9. Additionally, fluoxetine enhances the function of chemotherapy in aggressive glioma brain tumours. Ultimately, SSRIs increase levels of cell arresting compounds like p53 and p21 proteins. SSRIs have a dual-purpose in cancer by both targeting depression and cancer cell proliferation. SSRIs, at least fluoxetine, have potential as an enhancer to chemotherapy treatment.

Item Type: Thesis (Bachelor's Thesis)
Supervisor:
Supervisor nameSupervisor E mail
Buwalda, B.B.Buwalda@rug.nl
Degree programme: Life Science and Technology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 11 Jan 2019
Last Modified: 14 Jan 2019 11:31
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/19004

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