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Theoretical and experimental investigation of microbial growth and adhesion on 3D printing material: An alternative approach for bioreactor fabrication

Teeuwen, Elmar (2019) Theoretical and experimental investigation of microbial growth and adhesion on 3D printing material: An alternative approach for bioreactor fabrication. Research Project, Industrial Engineering and Management.

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Abstract

At the moment bioreactor processes are time consuming and costly. A new approach thathas been looked over for a long period of time is to develop a micro bioreactors systemwhich spreads the risk of contamination, reduce cost and results in higher experimentalthroughput. Upcoming manufacturing technologies have given new insights to design and fabricate miniature bioreactors in the field of microbiology. The new approach makes useof 3D printing to construct devices from 3D CAD designs. In this research photopolymer 3D printing is used to fabricate a bioreactor flask. The growth rates of Escherichia coli(E.coli) in 3D printed shaking flasks are compared to glass shaking flasks in a laboratory environment to determine if 3d printed material is biocompatible. The results show promising bacterial growth rates for E.coli in a 3D printed shaking reactor. Furthermore long term factors influencing the bacterial growth, such as bacterial adhesion have also been examined, however due to a limited time the bacterial adhesion experiment is only designed and no results are available yet. The designed experimental setup examines the bacterial adhesiveprobability of general and coated 3D printed material slides in comparison to glass slides.

Item Type: Thesis (Research Project)
Supervisor:
Supervisor nameSupervisor E mail
Euverink, G.J.W.G.J.W.Euverink@rug.nl
Degree programme: Industrial Engineering and Management
Thesis type: Research Project
Language: English
Date Deposited: 22 Jan 2019
Last Modified: 23 Jan 2019 10:11
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/19053

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