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An analysis of the relationship between metabolism and morphology in Escherichia coli and Bacillus subtilis

Van Essen, Rogier (2019) An analysis of the relationship between metabolism and morphology in Escherichia coli and Bacillus subtilis. Master's Thesis / Essay, Molecular Biology and Biotechnology.

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Abstract

Abstract This thesis looks into enzymes or metabolites involved in bacterial cells’ metabolism which are also involved in cell morphology and division. I will discuss several studies that identify genes coding for these metabolic enzymes or their products and substrates using using gene deletions, GFP fusions for localizations and heat sensitive ftsZ. A whole host of single genes in metabolic pathways seem to have an effect on cell size and growth rate. ppGpp and cAMP seem important metabolites for the control of both metabolism and cell morphology. cAMP possibly plays a role as inhibitor of Z-ring formation and as a regulator of cell width, whereas ppGpp seems to be a promoter of Z-ring formation and a regulator of cell length and width. Fatty acid metabolism also appears to play an important role as primary determinant of cell size.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor:
Supervisor nameSupervisor E mail
Scheffers, D.J.D.J.Scheffers@rug.nl
Degree programme: Molecular Biology and Biotechnology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 03 Feb 2019
Last Modified: 04 Mar 2019 12:09
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/19106

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