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Neuroinflammation and autism spectrum disorder: a review

Scheper, Silke (2019) Neuroinflammation and autism spectrum disorder: a review. Bachelor's Thesis, Biology.

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Abstract

Autism spectrum disorder (ASD) is a psychological disorder that affects 1-2 per 100 individuals. There is evidence that ASD patients display neuroinflammation. In this review, the link between ASD and neuroinflammation is highlighted. Several environmental factors are assessed, such as maternal inflammation, the amount in TNF-α in the ASD brain and functionality of the blood-brain barrier. We conclude that the maternal inflammation and autoimmune disease increase the risk of ASD, TNF-α is elevated in patients with ASD and the blood-brain barrier is dysfunctional. This implicates treatment of neuroinflammation in ASD patients rather than the original drug treatment. However, more research is needed to fully examine the neuroinflammation process in ASD patients.

Item Type: Thesis (Bachelor's Thesis)
Supervisor:
Supervisor nameSupervisor E mail
Havekes, R.R.Havekes@rug.nl
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 05 Mar 2019
Last Modified: 25 Mar 2019 12:36
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/19228

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