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The Effect of Early Life Stress on Epigenetic Programming of the Brain

Dongen, L. van The Effect of Early Life Stress on Epigenetic Programming of the Brain. Bachelor's Thesis, Biology.


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Early life stress causes epigenetic changes in the brain and those changes often result in altered behavior. A stressful experience can activate the HPA axis. The HPA axis releases glucocorticoids to prepare the organism for the stressor. Most of the epigenetic changes are regulated by DNA methylation and histone modification. Early life is the most vulnerable period for epigenetic changes to take place. Early life stress can alter gene expression in many brain regions and this effect is most of the time gene silencing. Most importantly, Bdnf expression in the hippocampus is reduced as a result of early life stress.

Item Type: Thesis (Bachelor's Thesis)
Supervisor nameSupervisor E mail
Zee, E.A. van derUNSPECIFIED
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 21 May 2019 09:40
Last Modified: 21 May 2019 09:40

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