Encapsulins, a new versatile class of nanocompartments and its applications in biotechnology

Dubach, Victor (2019) Encapsulins, a new versatile class of nanocompartments and its applications in biotechnology. Bachelor's Thesis, Biology.

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Abstract

Compartmentalization is found in almost all life. Although bacteria and archaea do not have organelles they do have proteinaceous compartments, one of which is the encapsulin nanocompartment. Encapsulins were recently discovered by Sutter et al. in 2008 and are found widespread in bacteria and archaea. More than 900 putative encapsulin genes were found among fifteen bacterial and two archaeal phyla. Even though much is still unknown about them, such as the self-assembly pathway, physiological role and origin, encapsulins have been shown to be promising for a variety of purposes. In this review the properties of encapsulins will be described such as cargo loading by a selective short peptide sequence at the C-terminal of the cargo, easy disassembly and reassembly in vitro and ease of shell modification. Examples of the application of encapsulins as imaging probes for specific (mammalian) cells, targeted therapeutic drug delivery and nanoreactors will be given to show the versatility and practicality of encapsulin nanocompartments.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Fraaije, M.W.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	21 May 2019
Last Modified:	22 May 2019 08:52
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/19510

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