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Dysbiosis in the Microbiome Associated with Inflammatory Bowel Disease and the Potential of Dietary Fibers

Wilmink, Marijn (2019) Dysbiosis in the Microbiome Associated with Inflammatory Bowel Disease and the Potential of Dietary Fibers. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

The microbiome is an important regulator in the development of the immune system. The complexity and composition of the microbiota are crucial for maintaining health and intestinal homeostasis. The Western, high-fat/low-fiber, diet causes vital changes in the composition of the microbiota and is correlated with the development of multiple Western diseases, such as inflammatory bowel disease (IBD). A well-balanced diet contains the right dietary fibers and is proven to be effective against the alteration of the gut microbiota. Whereat each dietary fiber is characterized by its own specific health benefits. The indirect effects mainly cause an increased level of short-chain fatty acids (SCFAs), but the dietary fibers can also affect receptors directly. Research discovered the TLR2 and 4 as the most commonly affected receptors. In this thesis, the increasing dysbiosis of the microbiota is discussed, in which the dietary fibers inulin, β-glucan, and pectin are discussed in association with their direct and indirect effects on the microbiota, immune system and intestinal health.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor:
Supervisor nameSupervisor E mail
Vos, P. dep.de.vos@umcg.nl
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 28 May 2019
Last Modified: 06 Jun 2019 12:13
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/19547

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