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Differences in regenerative capacity between organisms: an evaluation of the underlying mechanisms

Nagel, Elbrich Annette (2019) Differences in regenerative capacity between organisms: an evaluation of the underlying mechanisms. Bachelor's Thesis, Biology.

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Abstract

The capacity to regenerate varies greatly within the animal kingdom. Invertebrates like planarian flatworms and Hydra are very good regenerators, while mammals are only able to regenerate a limited amount of tissue and show a lot of scar formation. How the regenerative capacity can differ so profoundly between organisms has fascinated the scientific community for many years. In this review, several mechanisms and processes that might underly the differences in regenerative capacity amongst organisms will be discussed. It focusses on the cellular basis of regeneration, immune responses, expression of tumor suppressor genes, telomerase activity and cellular senescence. A better understanding of the role of these processes in regeneration could be useful for the development of new therapies to stimulate regeneration in mammals.

Item Type: Thesis (Bachelor's Thesis)
Supervisor:
Supervisor nameSupervisor E mail
Mouton, S.M.s.m.mouton@umcg.nl
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 08 Jul 2019
Last Modified: 10 Jul 2019 08:24
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/19989

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