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Astrocyte and microglia senescence in Parkinson's disease

Molenkamp, Willem Hendrik (2019) Astrocyte and microglia senescence in Parkinson's disease. Bachelor's Thesis, Life Science and Technology.


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Cellular senescence is a state of permanent cell arrest which is accompanied by multi- ple phenotypical changes including the secretion of pro-inflammatory mediators. These alterations have both beneficial and deleterious effects on the environment, making the occurrence of senescence important for various biological processes and pathologies. It is only since recently that research started to look at senescence in the CNS and several links with neurodegenerative diseases are already being established. Senescence in astrocytes and microglia may play an important role as their neuroinflammatory properties are known to contribute to neurodegenerative diseases like Parkinson’s Disease. In this review, we will try to answer what the molecular basis is behind senescence and how senescence in astrocytes and microglia may play a role in the pathology of Parkinson’s disease, emphasizing its contribution to neuroinflammation.

Item Type: Thesis (Bachelor's Thesis)
Supervisor nameSupervisor E mail
Degree programme: Life Science and Technology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 16 Jul 2019
Last Modified: 17 Jul 2019 09:11

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