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Multiple Myeloma : a bone eating disease

te Velde, Maurice (2019) Multiple Myeloma : a bone eating disease. Bachelor's Thesis, Biology.

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Abstract

Multiple myeloma (MM) is an incurable malignant neoplasm of plasma cells that are terminally differentiated. The disease is characterized by a disrupted immune system, anemia, bone destruction and organ damage. Elderly people are predominantly affected and have an overall 5-year survival rate close to 50%. The malignant plasma cells are located in the bone marrow, where the environment allows for uncontrolled growth. The bone marrow microenvironment (BMM) homes multiple chemical signaling-stromal cells that induce plasma cell proliferation and angiogenesis. Current treatment option are very expensive and often fail to prevent relapse of the cancer. Monoclonal gammopathy of undetermined significance, a pre-malignant state of MM, is asymptomatic and never progresses to MM in a vast majority. Prevention is always preferred over treatment of symptoms, interfering with the progression to MM could therefore be the solution. The heterogeneous mutational landscape of MM tumors shape diverse genetic alterations, but lack consistent mutational hallmarks which cause disease onset. This thesis reviewed how prevention of the progression to multiple myeloma can be achieved by targeting cell-interactions in the bone marrow microenvironment.

Item Type: Thesis (Bachelor's Thesis)
Supervisor:
Supervisor nameSupervisor E mail
Schuringa, J.J.j.j.schuringa@umcg.nl
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 18 Jul 2019
Last Modified: 23 Jul 2019 11:51
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/20332

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