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The microbiome modulating the body's response to cancer immunotherapy: potential for diagnostic and therapeutic practices

Lijnzaad, Dorien (2019) The microbiome modulating the body's response to cancer immunotherapy: potential for diagnostic and therapeutic practices. Bachelor's Thesis, Life Science and Technology.

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Abstract

In recent years, immunotherapy has revolutionized cancer therapy, showing impressive outcomes in many patients. However, responses vary greatly between individuals and their long-term effectiveness is unpredictable. The suggestion has been raised that the microbiome plays a role in the body’s response to immunotherapy. The link between oncogenesis and the microbiome has become increasingly evident although causal relations are difficult to identify. In 2018 it was discovered that different fecal microbiome composition in patients show different responses to checkpoint inhibitor therapy. In the quest for precision cancer therapy, the microbiome is a promising candidate for tailoring immunotherapy, for example through pre-screening patients for favourable microbiota, using specific microbiotic composition as a therapy adjuvant, or by means of fecal transplantation prior to therapy. In this article the diagnostic and therapeutic potential of the microbiome in modulating the body’s response to cancer immunotherapy is discussed.

Item Type: Thesis (Bachelor's Thesis)
Supervisor:
Supervisor nameSupervisor E mail
Laman, J.D.j.d.laman@umcg.nl
Harmsen, H.J.M.h.j.m.harmsen@umcg.nl
Degree programme: Life Science and Technology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 21 Jul 2019
Last Modified: 23 Aug 2019 12:17
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/20372

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