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Are iPSC-models the future of AD research?

Marques, Joao (2019) Are iPSC-models the future of AD research? Master's Thesis / Essay, Behavioural and Cognitive Neurosciences.

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Abstract

Alzheimer’s disease (AD) is an age-related neurodegenerative disease that affects a growing proportion of the human population. It is the main cause of dementia worldwide and, due to its increasing prevalence, it is estimated that the social and economic costs of caring for AD patients will have enormous impact on society. Thus, it is essential to understand the molecular basis of AD in order to develop more efficient therapies and reduce the burden of AD on society. The lack of appropriate in vitro and in vivo models has hindered the progress for understanding AD mechanisms. However, the recent development of iPSC technology has enabled researchers to establish human neuron cultures that mimic the genetic and phenotypic profiles of AD patients. Despite that, obstacles such as variability and improper neuronal maturation are currently barriers for the use of iPSC-based models for AD research. In this essay, the contributions and limitations of iPSC-based models for AD research will be discussed. Finally, this essay also explores the future directions of iPSC-based research in AD research, namely the development of 2D and 3D neuronal-glial co-culture methods.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor:
Supervisor nameSupervisor E mail
Dolga, A.M.A.M.Dolga@rug.nl
Degree programme: Behavioural and Cognitive Neurosciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 02 Aug 2019
Last Modified: 08 Aug 2019 10:40
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/20533

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